The absence of this chemical can lead to higher blood levels and the drug may become more potent. Researchers at the clinical pharmacology department at Radcliffe Infirmary in Oxford, England warned that grapefruit juice inhibits a chemical in the intestine needed to break down many drugs in the body. “Drinking grapefruit juice together with certain medicines can increase blood levels of the drug to harmful levels, a new report claims. Two recent articles that may be of interest are:ġ. It is not just the drug interaction, but chemical compounds within the grapefruit also can adversely effect the “healthy person” that does have some evidence of: Antiarrhythmic drugs such as amiodarone (Cordarone).Immunosuppressant drugs such as cyclosporine (Neoral, Sandimmune), tacrolimus (Prograf) and sirolimus (Rapamune).HMG-CoA reductase inhibitors such as simvastatin (Zocor), lovastatin (Mevacor) and atorvastatin (Lipitor).Human immunodeficiency virus (HIV) protease inhibitors such as saquinavir (Fortovase, Invirase) and indinavir (Crixivan).Calcium channel blockers such as felodipine (Plendil), nifedipine (Adalat, Procardia, nimodipine (Nimotop), nisoldipine (Sular) and possibly verapamil (Isoptin, Verelan).Benzodiazepines such as diazepam (Valium) and triazolam (Halcion).Antidepressants such as buspirone (BuSpar), clomipramine (Anafranil) and sertraline (Zoloft).Antiseizure drugs such as carbamazepine (Carbatrol, Tegretol).We also need to be very aware that this fruit has some significant detrimental side effects in addition to the acid creating potential, 2 of which are highlighted below:ĭrugs that are known to have potentially serious interactions with grapefruit products include: The grapefruit does inhibit the secretion within the GUT of essential enzymes which cannot function in the presence of this fruit and its chemical compounds. However this fruit should be considered as a medicine food and caution (perhaps even more than the orange) should be used when consuming it. There are health benefits that can be derived from the grapefruit and these include benefits for the heart, anti cancer and improved sleep patterns. For example, a banana with a few black spots that is almost ripe is more acidic, while a banana that is freshly ripened with a moderate amount of black spots is more alkaline. But when they are naturally ripe they are alkaline. When oranges (or grapefruit) are in an unripe state they are acid-forming. Tree ripened fruit contain higher concentrations of minerals like calcium and magnesium. Instead of the orange providing you with alkalizing calcium it now contributes to the build-up of acidity in the body. Mass produced oranges are also picked green and shipped to market to be ripened later, resulting in virtually no calcium and very little vitamin C. Another undesirable effect of consuming orange juice is tooth enamel erosion. In the absence of sweating, high acid residue can cause some undesirable liver problems. We need to be aware that the citric acid content within the orange is about 3.5 Ph and a conflict exists in colder climates because the body tries to sweat out the excess acids. We do not sweat out these toxins in our climate and, together with the increase in acidity, this is undesirable. This fruit does contain chemical compounds that can over stimulate the liver when consumed in temperate climates, releasing undesirable toxins from the liver that are free to “roam” our system. There is a big distinction to be made in so far as the chemistry of the broad citrus group is not ideal to our body needs in a temperate climate. One explanation is the high vitamin C content of citrus fruits - vitamin C is known to counteract nitrosamines, carcinogens that are implicated in stomach cancer. ![]() Research: Officials at the National Cancer Institute ( USA) believe that the increase the consumption of citrus fruits due to year-round availability has contributed to a reduction in the rate of stomach cancer in the USA.Citrus Fruits help to prevent Stomach Cancer.Research: Swedish researchers have found that citrus fruits are one of the most chosen food groups of populations with low rates of pancreatic cancer.Citrus Fruits help to prevent Pancreatic Cancer.Citrus Fruits help to prevent Inflammation (due to the Nobiletin content of Citrus Fruits).Citrus Fruits help to prevent Pharyngeal Cancer.Citrus Fruits help to prevent Esophageal Cancer.The general health benefits of citrus fruits within the Immune system is often considered because of the beneficial effects that citrus fruits hold to help prevent some types of cancer:
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